3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER
3-(2-pyridyldithio)propionic acid n-hydroxy-succinimide ester
CAS: 68181-17-9
Molecular Formula: C12H12N2O4S2
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER - Names and Identifiers
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER - Physico-chemical Properties
| Molecular Formula | C12H12N2O4S2 |
| Molar Mass | 312.36 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Melting Point | 84-86°C(lit.) |
| Boling Point | 465.9±55.0 °C(Predicted) |
| Solubility | acetone: 50mg/mL |
| Appearance | powder |
| Color | White to Light Yellow |
| BRN | 1548137 |
| pKa | 1.76±0.19(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic, Moisture Sensitive |
| In vitro study | Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP. |
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-10 |
| HS Code | 29333990 |
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER - Reference Information
| Biological activity | SPDP (SPDP Crosslinker) is a short-chain cross-linking agent that can pass through NHS-ester and pyridyl dithiol reactive groups and cysteine The sulfhydryl group forms a degradable (cleavable) (reducible) disulfide bond to realize the combination of amine and sulfhydryl group. SPDP (SPDP Crosslinker) is a degradable (cleavable) ADC linker that can be used to synthesize antibody-coupled drugs (ADC). |
| use | universal heterofunctional cross-linking agent for proteins and enzymes. |
Last Update：2024-04-09 02:00:04
